Literature: 本研究技術を用いた参考文献です。

Publicationlist of Quantitative Targeted Absolute Proteomics (QTAP) Research-2


Updated at October 6, 2018


In silico設計法に基づく標的絶対定量プロテオミクス技術を応用した研究成果で公表された論文リスト。(英語論文および著書は全て査読有)

5) Characterization of In Vitro and In Vivo Model

33.           Schaefer O, Ohtsuki S, Kawakami H, Inoue T, Liehner S, Saito A,Sakamoto A, Ishiguro N, Matsumaru T, Terasaki T, Ebner T., Absolute quantitation and differential expression ofdrug transporters, Cytochrome P450 Enzymes and UDP-Glucuronosyltransferases incultured primary human hepatocytes. Drug Metab. Dispos., 40(1):93-103 (2012).

34.         Agarwal S, Uchida Y, Mittapalli RK, Sane R, Terasaki T, Elmquist WF,Quantitative Proteomics of Transporter Expression in Brain CapillaryEndothelial Cells Isolated from P-gp, Bcrp, and P-gp/Bcrp KnockoutMice. Drug Metab. Dispos., 40(6):1164-1169 (2012).

35.          Ohtsuki S, Ikeda C,Uchida Y, Sakamoto Y, Miller F, Glacial F, Decleves X, Scherrmann JM, Couraud PO, Kubo Y, Tachikawa M, Terasaki T.,Quantitative targeted absolute proteomic analysis of transporters, receptorsand junction proteins for validation of human cerebral microvascularendothelial cell line hCMEC/D3 as a human blood-brain barrier model. Mol Pharm., 10(1):289-296 (2013).

36.          KazukiY, Kobayashi K, Aueviriyavit S, Oshima T, Kuroiwa Y, Tsukazaki Y, Senda N, KawakamiH, Ohtsuki S, Abe S, Takiguchi M, Hoshiya H, Kajitani N, Takehara S, Kubo K, Terasaki T, Chiba K, Tomizuka K, Oshimura M.Trans-chromosomic mice containing a human CYP3A cluster for prediction ofxenobiotic metabolism in humans. Hum Mol Genet. 22(3):578-592 (2013).

37.          Ohtsuki S, KawakamiH, Inoue T, Nakamura K, Tateno C, Katsukura Y, Obuchi W,Uchida Y, Kamiie J, Horie T, Terasaki T., Validation of uPA/SCID mousewith humanized liver as a human liver model: protein quantification oftransporters, cytochromes P450, and UDP-glucuronosyltransferases by LC-MS/MS, Drug MetabDispos. 42(6),1039-1043 (2014).

38.          Uchida Y, Ohtsuki S, Kamiie J, Ohmine K, Iwase R, Terasaki T., Quantitative targeted absolute proteomics for 28 humantransporters in plasma membrane of Caco-2 cell monolayer cultured for 2, 3, and4 weeks. Drug Metab. Pharmacokin., 30(2): 205-208 (2015).

39.          Gartzke D1, Delzer J, Laplanche L, Uchida Y,Hoshi Y, Tachikawa M, Terasaki T, Sydor J, Fricker G., Genomic Knockout of Endogenous Canine P-Glycoproteinin Wild-Type, Human P-Glycoprotein and Human BCRP Transfected MDCKII Cell Linesby Zinc Finger Nucleases. Pharm Res., 32(6):2060-2071 (2015).35.          Ohtsuki S, Ikeda C,Uchida Y, Sakamoto Y, Miller F, Glacial F, Decleves X, Scherrmann JM, Couraud PO, Kubo Y, Tachikawa M, Terasaki T.,Quantitative targeted absolute proteomic analysis of transporters, receptorsand junction proteins for validation of human cerebral microvascularendothelial cell line hCMEC/D3 as a human blood-brain barrier model. MolPharm., 10(1):289-296 (2013).

40.           Akazawa T,Uchida Y, Tachikawa M, Ohtsuki S, Terasaki T., Quantitative Targeted AbsoluteProteomics of Transporters and Pharmacoproteomics-Based Reconstruction ofP-Glycoprotein Function in Mouse Small Intestine. Mol Pharm.,13(7): 2443-2456 (2016). doi: 10.1021/acs.molpharmaceut.6b00196. 

41.          Pelkonen L, Sato K, Reinisalo M, Kidron H,Tachikawa M, Watanabe M, Uchida Y, Urtti A and Terasaki T, LC-MS/MS BasedQuantitation of ABC and SLC transporter proteins in plasma membranes ofcultured primary human retinal pigment epithelium cells and immortalized ARPE19cell line, Mol Pharm, 14(3):605-613 (2017).

42.          Akazawa T, Uchida Y, MiyauchiE, Tachikawa M, Ohtsuki S, Terasaki T, High Expression of UGT1A1/1A6 in Monkey SmallIntestine: Comparison of Protein Expression Levels of Cytochromes P450,UDP-Glucuronosyltransferases, and Transporters in Small Intestine of CynomolgusMonkey and Human. Mol Pharm. 15(1):127-140 (2018).
doi: 10.1021/acs.molpharmaceut.7b00772.

43.          Pan Y, Omori K, Ali I, Tachikawa M, Terasaki T,Brouwer KLR, Nicolazzo JA, Altered expression of small intestinal drugtransporters and hepatic metabolic enzymes in a mouse model of familialAlzheimer’s disease, Mol Pharm, 2018 Aug 3. doi: 10.1021/acs.molpharmaceut.8b00500. 

6) Application for the Analysis of Determinant Protein for the DrugSensitivity

44.         Ohmine K, KawaguchiK, Ohtsuki S, Motoi F, Egawa S, Unno M, Terasaki T, Attenuation of Phosphorylation by Deoxycytidine Kinaseis Key to Acquired Gemcitabine Resistance in a Pancreatic Cancer Cell Line:Targeted Proteomic and Metabolomic Analyses in PK9 Cells. Pharm. Res., 29(7):2006-2016 (2012).

45.          Obuchi W, Ohtsuki S, Uchida Y, Ohmine K, Yamori T, Terasaki T.,Identification of transporters associated with etoposide sensitivity of stomachcancer cell lines and methotrexate sensitivity of breast cancer cell lines byquantitative targeted absolute proteomics, MolPharmacol., 83(2):490-500(2013). 

46.          Braun C, Sakamoto A, Fuchs H, Ishiguro N, Suzuki S,Cui Y, Klinder K, Watanabe M, Terasaki T and Sauer A, Quantification oftransporter and receptor proteins in dog brain capillaries and choroid plexus:relevance for the distribution in brain and  CSF of selected BCRP and P-gp substrates,MolPharm. 14(10):3436-3447 (2017). doi:10.1021/acs.molpharmaceut.7b00449.

47.          Miura T, Tachikawa M, Ohtsuka H, Fukase K, NakayamaS, Sakata N, Motoi F, Naitoh T, Katayose Y, Uchida Y, Ohtsuki S, Terasaki T,Unno M. Application of quantitative targeted absolute proteomicsto profile protein expression changes of hepatic transporters and metabolizingenzymes during cholic acid-promoted liver regeneration. J Pharm Sci. 106: 2499-2508 (2017).  Feb 26. pii: S0022-3549(17)30127-2. doi:10.1016/j.xphs.2017.02.018.  

7) Prediction of In Vivo Drug Distribution in the Brain  

48.         Uchida Y, Ohtsuki S, Kamiie J and Terasaki T, Blood-Brain Barrier (BBB) pharmacoproteomics (PPx): Reconstruction of in vivo brain distribution of 11P-glycoprotein substrates based on the BBB transporter protein concentration,in vitro intrinsic transport activity, and unbound fraction in plasma and brainin mice. J. Pharmacol. Exp. Ther., 339 (2): 579-588(2011).

49.         Uchida Y, Wakayama K, Ohtsuki S, Chiba M, Ohe T, Ishii Y, Terasaki T.,Blood-Brain Barrier Pharmacoproteomics-based Reconstruction of the In-Vivo Brain Distribution ofP-glycoprotein Substrates in Cynomolgus Monkeys. J PharmacolExpTher. 350(3):578-588 (2014).

50.         Uchida Y, Ohtsuki S, Terasaki T., Pharmacoproteomics-based Reconstruction of In Vivo P-Glycoprotein Function atBlood-Brain Barrier and Brain Distribution of Substrate Verapamil in Pentylenetetrazole-kindled Epilepsy, Spontaneous Epilepsy and Phenytoin Treatment Models. Drug MetabDispos. 42: 1719-1726 (2014).

51.          Zhang Z, Tachikawa M, UchidaY, Terasaki T, Drug clearance from cerebrospinal fluid mediated by organicanion transporters 1 (Slc22a6) and 3 (Slc22a8) at arachnoid membrane of rats. MolPharm.,15(3):911-922(2018). doi: 10.1021/acs.molpharmaceut.7b00852. 

52.          TachikawaM, Sumiyoshiya U, Saigusa D, Sasaki K, Watanabe M, Uchida Y, Terasaki T, Liverzonation index of drug transporter and metabolizing enzyme protein expressionsin mouse liver acinus, Drug Metab Dispos, 46(5):610-618 (2018). doi: 10.1124/dmd.117.079244. 

8) Clinical Application

53.          Yoshikawa A, Nakada M, Ohtsuki S, Hayashi Y, Obuchi W, Sato Y, Ikeda C, Watanabe T,Kawahara Y, Hasegawa T, Sabit H, Kita D, Hayashi Y, Nakanuma Y, Terasaki T and HamadaJ, Recurrent anaplastic meningioma treated by sunitinib based on theabsolute quantitative proteomics. Neuropath. Appl. Neurobiol., 38: 105–110(2012).

54.           Yoneyama T, Ohtsuki S, Ono M, Ohmine K, Uchida Y, Yamada T, Tachikawa M, Terasaki T.Quantitative targeted absolute proteomics-based large-scale quantification of proline-hydroxylated α-fibrinogen in plasma for pancreatic cancer diagnosis. J Proteome Res. 12(2):753-762 (2013).

55.           OhmineK, KawaguchiK, Ohtsuki S, Motoi F, Ohtsuka H, Kamiie J, Abe T, Unno M and Terasaki T,Quantitative targeted proteomics of pancreatic cancer: Deoxycytidine kinaseprotein level correlates to progression-free survival of patients receivinggemcitabine treatment, Mol. Pharm., 12(9):3282-91(2015).  doi:10.1021/acs.molpharmaceut.5b00282

56.           Lloret-Linares C., Miyauchi E.,Luo H., Labat L., Bouillot JL., Poitou C., Oppert JM., Laplanche JL., Mouly S.,Scherrmann JM., Uchida Y., Tachikawa M., Terasaki T., Bergmann JF., DeclèvesX., Oral morphine pharmacokinetic in obesity: the role of P-glycoprotein, MRP2,MRP3, UGT2B7 and CYP3A4 jejunal contents and obesity-associated biomarkers, Mol.Pharm., 13(3):766-773 (20016). doi: 10.1021/acs.molpharmaceut.5b00656.

57.          Yoneyama T, Ohtsuki S, Honda K, Kobayashi M,Iwasaki M, Uchida Y, Okusaka T, Nakamori S, Shimahara M, Ueno T, Tsuchida A, SataN, Ioka T, Yasunami Y, Kosuge T, Kaneda T, Kato T, Yagihara K, Fujita S, HuangW, Yamada T, Tachikawa M and Terasaki T, Identification of IGFBP2 and IGFBP3 asCompensatory Biomarkers for CA19-9 in Early-Stage Pancreatic Cancer Using aCombination of Antibody-based and LC-MS/MS-based Proteomics. PLoS One,11(8): e0161009. (2016) doi:10.1371/journal.pone.0161009 

58.           Armania N,Hoshi Y, Yoneyama T, Miyauchi E, Tachikawa M, Watanabe M and Terasaki T, Globaland Targeted Proteomics of Prostate Cancer Cell Secretome: Combination of2-Dimensional Image-Converted Analysis of Liquid Chromatography and MassSpectrometry (2DICAL) and In Silico Selection SRM Analysis. J Pharm Sci.,105(11):3440-3452 (2016)

59.         Miyauchi E,Furuta T, Ohtsuki S, Tachikawa M, Uchida Y, Sabit H, Obuchi W, Baba T, WatanabeM, Terasaki1 T, Nakada M, Identification of blood biomarkers in glioblastoma bySWATH mass spectrometry and quantitative targeted absolute proteomics, PLOSONE, 13(3):e0193799(2018). doi: 10.1371/journal.pone.0193799. eCollection 2018.


9) Miscellaneous

60.       Ito S., Matsumiya K., Ohtsuki S., Kamiie J., Terasaki T., Contributions of degradation and elimination acrossthe blood-brain barrier to cerebral clearance of human amyloid-betapeptide(1-40) in mouse brain. J. Cereb. Blood Flow Metab.,33(11):1770-1777 (2013).

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